Dr. Huisingh-Scheetz uses her background in Geriatrics and Epidemiology to study the role of activity in the pathophysiology of frailty and aging. As a clinician investigator and NIA K23 recipient, her research has focused on understanding how objectively measured activity and sedentary behavior patterns, resting metabolic rate, and body composition relate to frailty progression and frailty-related outcomes. Through her work, she analyzes accelerometry data to assess and trend activity patterns as markers of frailty and to inform frailty activity interventions using the National Social Life, Health and Aging Project dataset, the National Health and Nutrition Examination Survey dataset, and local data. In partnership with NORC and Orbita, Inc, Dr. Huisingh-Scheetz also developed and is studying the impact of EngAGE, a technology-based tool utilizing a voice assistant to deliver exercise programming to older adults in their home to reduce frailty. The program leverages caregivers to provide social motivation to the older adult to simultaneously combat loneliness.